What is Evorelconti?
Evorel Conti is a hormone replacement therapy (HRT) patch used by women after menopause. It contains two hormones;
- Estrogen: for replace the estrogen your body stops producing after menopause.
- Progestogen: for protect the lining of the womb and reduce the risk of womb cancer.
Patch is applied to the skin and releases hormones steadily to help relieve menopause symptoms like hot flashes, night sweats, mood changes and to prevent bone thinning (osteoporosis).
Clinical Trials And Statistics Of Evorelconti
Bleeding Patterns;
- Initial Bleeding: In women initiating Evorel Conti after a hormone free period of at least two weeks; 33% experienced no bleeding during the first three months of treatment. This increased to 54% being bleed-free during the second and third months.
- Long-Term Bleeding: Over 12-month period 63% of women were bleed-free during the last three months of therapy. In women who were well-established in menopause (mean of 7 years since last menstrual period), 56% were bleed-free during the first three months, increasing to 92% during months 10 to 12.
What Are The Side Effects Of Evorelconti?
Very Common (≥10%):
- Application site reactions (e.g., redness, itching, rash): 11.7%
Common (≥1% to <10%):
- Headache: 8.2%
- Menstrual disorders: 7.1%
- Breast pain: 5.1%
- Depression: 2.6%
- Insomnia: 1.0%
- Anxiety: 1.0%
- Nervousness: 2.6%
- Paraesthesia: 1.0%
- Palpitations: 2.6%
- Hypertension: 3.6%
- Varicose veins: 1.0%
- Vasodilation: 2.6%
- Abdominal pain: 4.1%
- Diarrhoea: 2.6%
- Nausea: 2.6%
- Rash erythematous: 1.0%
- Arthralgia: 3.1%
- Back pain: 2.6%
- Cervical polyp: 1.0%
- Endometrial hyperplasia: 1.0%
- Genital discharge: 1.5%
- Dysmenorrhoea: 1.0%
- Menorrhagia: 1.0%
- Metrorrhagia: 3.6%
- Pain: 1.0%
- Oedema: 4.1%
- Fatigue: 3.1%
- Weight increased: 2.0%
Uncommon (≥0.1% to <1%):
- Candidiasis: 1.0%
- Libido decreased: 1.0%
- Migraine: 1.0%
- Flatulence: 1.0%
- Pruritus: 1.0%
- Myalgia: 1.0%
- Generalised oedema: 1.0%
Note: These statistics are based on clinical trial data and post marketing experiences. Personal experiences could be change.
What Are The Evorelconti Alternatives?
1. Other HRT Patches
- Evorel Sequi: Similar patch but designed for women in the early stages of menopause who still have periods. It provides a sequential combination of hormones.
- Estradot, Climara or FemSeven Conti: These are continuous combined HRT patches like Evorel Conti. They releasing both estrogen and progestogen.
2. HRT Tablets
- Kliovance: Low dose continuous combined HRT in tablet form.
- Elleste Duet Conti: Provides a continuous supply of hormones. It suitable for postmenopausal women.
- Femoston Conti: Another combined HRT tablet option with different hormone formulations.
3. HRT Gels or Creams
- Oestrogel: An estrogen-only gel applied to the skin. It combined with a separate progestogen if needed.
- Sandrena Gel: A similar estrogen-only gel option.
4. Progestogen-Only Options
For women who need progestogen supplementation beside estrogen;
- Mirena Coil (IUS): Progestogen-releasing intrauterine system that can be used beside estrogen-only HRT.
5. Non-Hormonal Alternatives
For women who can’t or choose not to use hormones;
- Clonidine: Prescription medication that helps manage hot flashes.
- SSRIs or SNRIs: Some antidepressants (like venlafaxine or fluoxetine) could reduce menopause symptoms.
- Herbal Remedies: Black cohosh or red clover (evidence for their effectiveness is limited).
Factors to Consider When Choosing Alternatives
- Medical history: Certain conditions (e.g., breast cancer, blood clots) could limit HRT options.
- Symptoms: Severity and type of menopause symptoms may guide the choice.
- Personal preference: The method of administration (patch, pill, gel, etc.) may influence the decision.
What’s The Differences Between Evorel Sequi And Evorel Conti?
Main difference between Evorel Sequi and Evorel Conti lies in how they are used and the hormones they provide. Both are hormone replacement therapy (HRT) patches but they are designed for different stages of menopause. Here’s a guide for you;
Evorel Sequi
- Who it’s for: Women in the early stages of menopause who are still having periods (perimenopause) or have had their last period recently.
- Hormones: Sequential HRT;
- Weeks 1-2: Patches contain estradiol (estrogen only).
- Weeks 3-4: Patches contain estradiol + norethisterone (estrogen + progestogen).
- How it works: Progestogen is added in the second half of the cycle to protect the womb lining and mimic the natural menstrual cycle.
- Bleeding pattern: Causes a monthly withdrawal bleed (similar to a period).
Evorel Conti
- Who it’s for: Postmenopausal women who haven’t had a period for at least 12 months.
- Hormones: Continuous combined HRT;
- Each patch contains estradiol + norethisterone (estrogen + progestogen).
- How it works: Delivers both hormones continuously without a break for maintain steady levels.
- Bleeding pattern: Designed to prevent monthly bleeding but some spotting could be seen initially.
Key Differences at a Glance
| Feature | Evorel Sequi | Evorel Conti |
|---|---|---|
| Intended users | Perimenopausal women | Postmenopausal women |
| Hormone delivery | Sequential (changes every 2 weeks) | Continuous (steady release) |
| Bleeding pattern | Monthly withdrawal bleed | No regular bleeding (spotting possible initially) |
| Goal | Mimic a natural cycle | Provide steady hormone support |
Choosing Between Them
The choice depends on where you are in your menopause journey;
- If you’re still having periods or in the early stages of menopause → Evorel Sequi.
- If you’re postmenopausal and haven’t had a period for over a year → Evorel Conti.
Where is The Best Place To Put Evorel Patches?
The best place to apply Evorel patches is on a clean, dry and hairless area of your lower body. Proper placement ensures the patch stays secure and delivers hormones effectively. Here’s a guide about how to choose the best area;
Recommended Areas
- Buttocks: One of the most common and effective areas.
- Lower abdomen: Below the waistline and avoiding the navel.
Tips for Application
- Avoid irritated or damaged skin: Don’t place the patch on cuts, rashes or irritated skin.
- Choose a flat surface: Helps the patch adhere properly without wrinkling.
- Avoid areas with folds or creases: E.g., waistlines, as movement can loosen the patch.
- Rotate the site: Change the location each time you apply a new patch to avoid skin irritation.
Where NOT to Apply
- Breasts: Don’t apply the patch on or near the breasts.
- Oily or sweaty skin: Patch couldn’t stick well.
- Areas exposed to tight clothing: Tight waistbands can rub against the patch and dislodge it.
How to Apply the Patch:
- Clean the area with water (no lotions, oils or powders).
- Peel off the protective liner.
- Press the patch firmly onto the skin for about 10 seconds.
What Are The Side Effects Of Stopping Evorel Conti Suddenly?
1. Return of Menopause Symptoms
Stopping hormone replacement therapy (HRT) suddenly can lead to menopause symptoms to return sometimes more intensely than before.
- Hot flashes and night sweats.
- Mood swings or irritability.
- Fatigue or low energy.
- Sleep disturbances (insomnia).
- Vaginal dryness or discomfort.
2. Bone Health Risks
HRT helps maintain bone density and reduces the risk of osteoporosis. Stopping suddenly may accelerate bone loss. Especially if you’re at high risk for osteoporosis or fractures.
3. Cardiovascular Health
HRT can have a protective effect on heart health for some women. Stopping suddenly may increase the risk of cardiovascular issues particularly in women with pre-existing conditions.
4. Emotional and Psychological Effects
Some women experience mood swings, anxiety or depressive symptoms when they stop HRT suddenly. This may be because of hormonal fluctuations or the return of menopause-related mood changes.
5. Weight Changes
HRT can help regulate weight distribution. Stopping it may cause to changes in weight or fat distribution particularly around the abdomen.
How to Stop Evorel Conti Safely?
- Gradual tapering: Slowly reducing the dose or frequency of the patches allows your body to adjust to lower hormone levels and minimizes withdrawal symptoms.
- Consult your doctor: Discuss your reasons for stopping and create a tailored plan. Your doctor may suggest alternative treatments for manage symptoms or protect bone health.
Tips for Managing Symptoms After Stopping
- Lifestyle changes: Eat a balanced diet, exercise regularly and avoid triggers like caffeine or alcohol that can worsen hot flashes.
- Non-hormonal treatments: Consider medications like SSRIs or herbal remedies to manage symptoms.
- Bone health: Be sure adequate calcium and vitamin D intake and consider medications if needed.
We wish healthy and happy life to you. Also you can find details about conjugated estrogens for menopause in below:
